Senior Scientist/Manager, Biologics/Biomaterials Laboratory
Education
Ph.D., M.S., Biomedical Engineering, Stony Brook University, Stony Brook, New York
B.A., Psychology, University of California at Santa Barbara, Santa Barbara, California
Appointments
Adjunct Professor, University of Memphis, Department of Biomedical Engineering
Adjunct Professor, Univresity of Tennessee Health Science Center, Department of Orthopaedics
Experience
Post-Doctoral Fellow, Integrative Biology, Eli Lily and Company, Indianapolis, Indiana
Orthopaedics Research Laboratory, Indiana University, Indianapolis, Indiana
Research Assistant, Molecular & Cellular Bioengineering Lab, Stony Brook University, Stony Brook, New York
Expertise
Animal models of orthopaedic disease and injury
Histology, Immunohistochemistry, Immunoprecipitation
Gene cloning
Micro computed tomography
Microscopy
Northern and Western blots
Recombinant and fusion proteins
RNA, DNA, and protein isolation
Tissue culture
Real time PCR
Microarrays
HPLC analysis
Patents
Mustang, a gene and nuclear protein. US Patent #7,238,799.
Publications
Komatsu, D.E., Mary, M.N., Schroeder, R.J., Robling, A.G., Turner, C.H., and Warden, S.J. Modulation of Wnt signaling during fracture repair. (Epub ahead of print) Read Abstract
Kumatsu D.E., Warden S.J. The control of fracture healing and its therapeutic targeting: improving upon nature. J Cell Biochem. 2010 109(2):302-11. Read Abstract.
Warden, S.J., Komatsu, D.E., Rydberg, J., Bond, J.L., and Hassett, S.M. Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing. Bone 2009 44:485-94. Read Abstract
Komatsu, D.E., Brune, K.A., Liu, H., Schmidt, A.L., Han, B., Zeng, Q.Q., Yang, X., Nunes, J.S., Lu, Y., Geiser, A.G., Ma, Y.L., Wolos, J.A., Westmore, M.S., and Sato, M. Longitudinal in vivo analysis of the region specific efficacy of PTH in a rat cortical defect model. Endocrinology 2009 150:1570-9.Read Abstract
Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou, M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J Bone Miner Res. 2007; 22: 366-374. Read Abstract
Komatsu DE, Hadjiargyrou M. Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone. 2004; 34:680-688. Read Abstract
Lombardo, F., Komatsu, D. and Hadjiargyrou, M. Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during skeletal development and regeneration. The FASEB Journal. 2004; 18: 52-61. Read Abstract